CD55 Antibody Catalog Number:OM274779
CD55monoclonalantibodywasraisedagainstHPB-ALLhumanTcellline(Human).KeyFeatureClonalityMonoclonalIsotypeIgMHostSpeciesMouseTestedApplicationsFACSIHCIPFACS,IHC-P(10ug/ml),IP:SpeciesReactivityHumanPrimateConcentration1mg/mlPurificationAffinitypurifiedTarget...
复宏汉霖亮相World ADC Asia 2024,分享ADC创新研发成果
HLX42isanext-generationEGFR-targetingADC,comprisedofahigh-affinityhumanizedIgG1antibodytargetingEGFR,conjugatedtoanoveltopoisomerase-Iinhibitorpayloadwhosecleavageandreleasearetumormicroenvironmentdependentanddonotrequireinternalizationbytumorcellsintolysosomes....
体内实验级重组人IgG1同型对照抗体 - Syd Labs
注意事项:最便宜的体内实验级重组人IgG1kappa同型对照和突变体(InVivoGradeRecombinantHumanIgG1kappaIsotypeControlAntibodymutant)。与经测试的人体样本的特异性结合程度低或无特异性结合。人源化可变区和人IgG1kappa恒定区。可提供嵌合版本和优质级(内毒素≤0.05EU/mg)。PA007125:体内实验级...
Nature:顺利穿越血脑屏障的抗体工程
Ashehadpredicted,thelower-affinityantibodywasdistributedmorebroadlyinthebrain2.WattsandDennislikenthetransportationofmoleculesbythereceptortoaskilift."Thehigh-affinityantibodiesnevergetofftheskilift,"saysWatts."Thelow-affinityantibodiesgetoffand...
临床试验:重组人狂犬病单克隆抗体的应用效果
通过捕获与片段结晶(Fc)区结合的配体修饰的膜中的单克隆抗体进行快速定量DOI:10.1021/acs.analchem.3c00531⑥Immunology:InhibitingN-glycanprocessingincreasestheantibodybindingaffinityandeffectorfunctionofhumannaturalkillercells抑制N-聚糖进程可增加人类自然杀伤细胞的抗体结合亲和力和效应功能...
【全球首个】GLP-1R/GIPR/GCGR三激动剂项目启动Ⅲ期临床
BiotinylatedHumanGCGR/Glucagonreceptor,His,AvitagimmobilizedonCM5ChipcanbindGLP-1(7-37)withanaffinityconstantof48.5μMasdeterminedinaSPRassay(Biacore8K)(QCtested).ACROBiosystems百普赛斯全面助力抗体药物研发,在原有的靶点蛋白业务基础上推出了以:ADCC及ADCP功能验...
降低亲和度可作为增强免疫调节抗体激动作用的策略
receptorfamiliesandshedlightonthemechanismofantibody-mediatedreceptorsignalling.Suchaffinityengineeringoffersarational,efficientandhighlytuneablesolutiontodeliverantibody-mediatedreceptoractivityacrossarangeofpotenciessuitablefortranslationtothetreatmentofhuman...
c-Kit/SCF信号轴概述及病理生理作用
5.E.K.Makowskietal.Co-optimizationoftherapeuticantibodyaffinityandspecificityusingmachinelearningmodelsthatgeneralizetonovelmutationalspace.NatureCommunications2022.6.W.Jiangetal.Bispecificc-Met/PD-L1CAR-TCellsHaveEnhancedTherapeuticEffectsonHepatocellular...
Future Medicine设计:计算模型HALA辅助解决ADC疗法痛点
为了解决这个问题,作者利用计算模型设计了一种高亲合力(Avidity)、低亲和力(Affinity)(HALA)载体抗体,在高表达细胞中ADC结合能受到部分阻断,从而提高组织渗透性。HALA抗体不能与低表达细胞中的ADC竞争,从而能让ADC与大多数受体结合。因此,载体剂量的竞争量会自动调整到表达水平,从而允许不同患者、转移瘤之间的定制竞争...
对抗体核心岩藻糖进行定点化学酶修饰增强其Fcγ受体亲和力与ADCC...
with6-azide-or6-hydroxy-l-fucose(l-galactose)significantlyenhancedtheantibody’saffinityforFcγRIIIareceptorsandsubstantiallyincreasedtheADCCactivity.Tounderstandthemechanismofthemodifiedfucose-mediatedaffinityenhancement,weperformedmoleculardynamicssimulations.Our...